Dr. Alessandra Bulotta

Specialised Oncologist

Melanoma – Lung Cancer – Pleural Mesothelioma – Thymus Cancer

IRCCS San Raffaele Hospital in Milan (since 2009)

– Staff Physician at the Division of Medical Oncology, in the department of Medical Oncology of the Ospedale San Raffaele in Milano.

Clinical and research activity

Doctor Alessandra Bulotta is specialised in the treatment of melanoma and thoracic neoplasms (lung tumour, thymus tumour and pleural mesothelioma).

Doctor Bulotta performs clinical activity, prescribes chemotherapy and support therapies, performs day Hospital activities and research activities: phase I, II and III protocols and research focused on the study of thoracic tumours (lung, pleura and thymus) and malignant melanomas.

Dr. Bulotta works in a team that contributes to the creation and management of clinical trials with both national and international relevance and is involved in activities related to the registration of new drugs.

Teaching Activity

Doctor Bulotta holds teaching positions in the Medicine and Surgery degree courses at the l’Università Vita e Salute of the Ospedale San Raffaele in Milano.

Doctor Bulotta also supports students in their clinical experience and plays a supporting role in their preparation of their Bachelor’s degree thesis, specialisation and PhD.

Other Activites

Project Manageer and Scientific Board Coordinator of the website LungCancers.eu and Tumorealpolmone.it

In 2018 She has revised the contents of skin tumours and melanoma of the website Ultraspecialisti.com


Degree in Medicine and Surgery at the Università Magna Grecia di Catanzaro (2004).

Specialisation in Medical Oncology at the Magna Grecia University of Catanzaro (2009).

Registered with the Certified Order of Doctors "Albo dei Medici"

Registered with the Certified Medical Association, Catanzaro n° 6451.

Previous assignments

From 2004 to 2009, she perfomed pre-clinical research (in vitro and in vivo studies of experimental therapies on human tumours) at the Department of Experimental Clinical Medicine – Medical Oncology Laboratory of the Università Magna Grecia of Catanzaro.

From 2005 to 2009 Dr. Bulotta has served as a substitute General Practitioner at the ASP in Catanzaro.

From 2006 to 2009 Dr. Bulotta has also served for the U.O. di Cure Primarie at the Provincial Health Service of Catanzaro.


Italian – English

Treated cancer diseases

Lung Cancer
Pleural Mesothelioma
Thymus Cancer

San Raffaele Hospital
Department of Medical Oncology
Via Olgettina 60
20132 Milan, Italy


Per prenotare una visita ambulatoriale in libera professione: +39 02 26436560

Per prenotare una visita ambulatoriale tramite SSN: +39 02 26432643

Online medical consultation with Dr. Bulotta

Adjuvant therapy for the treatment of Melanoma

Adjuvant therapy for the treatment of Melanoma

Adjuvant therapy for the treatment of Melanoma. The results of new studies to eliminate recurrences Article by Dr. Alessandra BulottaOncologist…

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Skin tumors … “enemies of the skin”!

Skin tumors … “enemies of the skin”!

Skin tumors … “enemies of the skin”! Article by Dr. Alessandra BulottaOncologist specialized in MelanomaSan Raffaele Hospital in Milano The…

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Dr. Bulotta is author and co-author of numerous scientific medical publications and plays an active role in the promotion of medical knowledge through the publication of articles in important scientific journals of undisputed oncological relevance (Lancet Oncology, Lung Cancer, Journal of Clinical Oncology, Clinical Cancer Research, Cancer, JNCI etc.)


Identification and monitoring of somatic mutations in circulating cell-free tumor DNA in lung cancer patients.
Francaviglia I, Magliacane G, Lazzari C, Grassini G, Brunetto E, Dal Cin E, Girlando S, Medicina D, Smart CE, Bulotta A, Gregorc V, Pecciarini L, Doglioni C, Cangi MG.
Lung Cancer. 2019 Aug;134:225-232. doi: 10.1016/j.lungcan.2019.06.010.

PD-1 Inhibitors-Related Neurological Toxicities in Patients with Non-Small-Cell Lung Cancer: A Literature Review.
Mirabile A, Brioschi E, Ducceschi M, Piva S, Lazzari C, Bulotta A, Viganò MG, Petrella G, Gianni L, Gregorc V.
Cancers (Basel). 2019 Mar 1;11(3). pii: E296. doi: 10.3390/cancers11030296.

Temozolomide in combination with either veliparib or placebo in patients with relapsed-sensitive or refractory small-cell lung cancer.
Lazzari C, Gregorc V, Bulotta A, Dottore A, Altavilla G, Santarpia M.
Transl Lung Cancer Res. 2018 Dec;7(Suppl 4):S329-S333. doi: 10.21037/tlcr.2018.12.02.

Combined exosomal RNA and circulating tumor DNA for epidermal growth factor mutation detection in non-small cell lung cancer.
Lazzari C, Gregorc V, Cangi MG, Giovannetti E, Bulotta A, Santarpia M.
J Thorac Dis. 2018 Nov;10(Suppl 33):S4023-S4027. doi: 10.21037/jtd.2018.10.17.

Efficacy of ALK inhibitors on NSCLC brain metastases: A systematic review and pooled analysis of 21 studies.
Petrelli F, Lazzari C, Ardito R, Borgonovo K, Bulotta A, Conti B, Cabiddu M, Capitanio JF, Brighenti M, Ghilardi M, Gianni L, Barni S, Gregorc V.
PLoS One. 2018 Jul 27;13(7):e0201425. doi: 10.1371/journal.pone.0201425. eCollection 2018.

Combination of immunotherapy with chemotherapy and radiotherapy in lung cancer: is this the beginning of the end for cancer?
Lazzari C, Karachaliou N, Bulotta A, Viganó M, Mirabile A, Brioschi E, Santarpia M, Gianni L, Rosell R, Gregorc V.
Ther Adv Med Oncol. 2018 Apr 6;10:1758835918762094. doi: 10.1177/1758835918762094. eCollection 2018.

Preoperative management of children with esophageal atresia: current perspectives.
Parolini F, Bulotta AL, Battaglia S, Alberti D.
Pediatric Health Med Ther. 2017 Jan 18;8:1-7. doi: 10.2147/PHMT.S106643. eCollection 2017.

Second-line therapy of squamous non-small cell lung cancer: an evolving landscape.
Lazzari C, Karachaliou N, Gregorc V, Bulotta A, Gonzalez-Cao M, Verlicchi A, Altavilla G, Rosell R, Santarpia M.
Expert Rev Respir Med. 2017 Jun;11(6):469-479. doi: 10.1080/17476348.2017.1326822. Epub 2017 May 15.

“Trident" preputial plasty for phimosis in childhood.
Pedersini P, Parolini F, Bulotta AL, Alberti D.
J Pediatr Urol. 2017 Jun;13(3):278.e1-278.e4. doi: 10.1016/j.jpurol.2017.01.024.

Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome.
Molinaro F, Garzi A, Cerchia E, Di Crescenzo VG, Luzzi L, Bulotta AL, Gotti G, Messina M.
Open Med (Wars). 2016 Jun 23;11(1):196-199. doi: 10.1515/med-2016-0037. eCollection 2016.

The complex interplay between clinical and person-centered diabetes outcomes in the two genders.
Rossi MC, Lucisano G, Pintaudi B, Bulotta A, Gentile S, Scardapane M, Skovlund SE, Vespasiani G, Nicolucci A; BENCH-D Study Group.
Health Qual Life Outcomes. 2017 Feb 21;15(1):41. doi: 10.1186/s12955-017-0613-0.

Historical Evolution of Second-Line Therapy in Non-Small Cell Lung Cancer.
Lazzari C, Bulotta A, Ducceschi M, Viganò MG, Brioschi E, Corti F, Gianni L, Gregorc V.
Front Med (Lausanne). 2017 Jan 23;4:4. doi: 10.3389/fmed.2017.00004. eCollection 2017.

Circumcision with Glubran(®) 2 in children: experience of Italian Center.
Angotti R, Cerchia E, Molinaro F, Bulotta AL, Ferrara F, Bindi E, Messina M.
Gland Surg. 2016 Aug;5(4):391-7. doi: 10.21037/gs.2016.03.03.

Nonmuscular Invasive Urothelial Carcinoma of the Bladder in Pediatric and Young Adult Patients: Age-related Outcomes.
Caione P, Patruno G, Pagliarulo V, Bulotta AL, Salerno A, Diomedi Camassei F, Lastilla G, Gerocarni Nappo S.
Urology. 2017 Jan;99:215-220. doi: 10.1016/j.urology.2016.07.009.

Isolated Vaginal Agenesis Associated with Multiple Gastrointestinal Anomalies: A Case Report.
Angotti R, Molinaro F, Bulotta AL, Ferrara F, Sica M, Bindi E, Messina M.
J Neonatal Surg. 2016 Jul 3;5(3):32. doi: 10.21699/jns.v5i3.326. eCollection 2016 Jul-Sep.

Endoscopic management of sigmoid volvulus in children.
Parolini F, Orizio P, Bulotta AL, Garcia Magne M, Boroni G, Cengia G, Torri F, Alberti D.
World J Gastrointest Endosc. 2016 Jun 25;8(12):439-43. doi: 10.4253/wjge.v8.i12.439.

Continence and quality of life with the modified Heitz-Boyer-Hovelacque rectal bladder for children with urinary incontinence following bladder exstrophy.
Messina M, Molinaro F, Ferrara F, Angotti R, Bulotta AL, Di Maggio G, Bianchi A.
J Pediatr Urol. 2016 Jun;12(3):174.e1-6. doi: 10.1016/j.jpurol.2015.12.010.

Correlates of diabetes-related distress in type 2 diabetes: Findings from the benchmarking network for clinical and humanistic outcomes in diabetes (BENCH-D) study.
Pintaudi B, Lucisano G, Gentile S, Bulotta A, Skovlund SE, Vespasiani G, Rossi MC, Nicolucci A; BENCH-D Study Group.
J Psychosom Res. 2015 Nov;79(5):348-54. doi: 10.1016/j.jpsychores.2015.08.010.

Interplay among patient empowerment and clinical and person-centered outcomes in type 2 diabetes. The BENCH-D study.
Rossi MC, Lucisano G, Funnell M, Pintaudi B, Bulotta A, Gentile S, Scardapane M, Skovlund SE, Vespasiani G, Nicolucci A; BENCH-D Study Group.
Patient Educ Couns. 2015 Sep;98(9):1142-9. doi: 10.1016/j.pec.2015.05.012.

Herlyn-Werner-Wunderlich syndrome: An “early" onset case report and review of Literature.
Angotti R, Molinaro F, Bulotta AL, Bindi E, Cerchia E, Sica M, Messina M.
Int J Surg Case Rep. 2015;11:59-63. doi: 10.1016/j.ijscr.2015.04.027.

Uncommon surgical emergencies in neonatology.
Angotti R, Bulotta AL, Ferrara F, Molinaro F, Cerchia E, Meucci D, Messina M.
Pediatr Med Chir. 2014 Dec 30;36(5-6):99. doi: 10.4081/pmc.2014.99.

Preoperative distraction in children: hand-held videogames vs clown therapy.
Messina M, Molinaro F, Meucci D, Angotti R, Giuntini L, Cerchia E, Bulotta AL, Brandigi E.
Pediatr Med Chir. 2014 Dec 30;36(5-6):98. doi: 10.4081/pmc.2014.98.

Rare case of an adrenocortical neoplasm: A case report and review of literature.
Angotti R, Molinaro F, Bulotta AL, DI Maggio G, Brandigi E, Messina M.
Oncol Lett. 2014 Dec;8(6):2705-2708.

Predictive value of a proteomic signature in patients with non-small-cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarker-stratified, randomised phase 3 trial.
Gregorc V, Novello S, Lazzari C, Barni S, Aieta M, Mencoboni M, Grossi F, De Pas T, de Marinis F, Bearz A, Floriani I, Torri V, Bulotta A, Cattaneo A, Grigorieva J, Tsypin M, Roder J, Doglioni C, Levra MG, Petrelli F, Foti S, Viganò M, Bachi A, Roder H.
Lancet Oncol. 2014 Jun;15(7):713-21. doi: 10.1016/S1470-2045(14)70162-7.

Surgical retroperitoneoscopic and transperitoneoscopic access in varicocelectomy: duplex scan results in pediatric population.
Mancini S, Bulotta AL, Molinaro F, Ferrara F, Tommasino G, Messina M.
J Pediatr Urol. 2014 Dec;10(6):1037-42. doi: 10.1016/j.jpurol.2014.02.017.

Mechanisms of resistance to EGFR tyrosine kinase inhibitors gefitinib/erlotinib and to ALK inhibitor crizotinib.
Tartarone A, Lazzari C, Lerose R, Conteduca V, Improta G, Zupa A, Bulotta A, Aieta M, Gregorc V.
Lung Cancer. 2013 Sep;81(3):328-336. doi: 10.1016/j.lungcan.2013.05.020.

Ambiguous external genitalia due to defect of 5-α-reductase in seven Iraqi patients: prevalence of a novel mutation.
Di Marco C, Bulotta AL, Varetti C, Dosa L, Michelucci A, Baldinotti F, Meucci D, Castagnini C, Lo Rizzo C, Di Maggio G, Simi P, Mari F, Bertelloni S, Renieri A, Messina M.
Gene. 2013 Sep 10;526(2):490-3. doi: 10.1016/j.gene.2013.04.070.

Chromosome 18q-syndrome and 1p terminal duplication in a patient with bilateral vesico-ureteral reflux: case report and literature revision.
Brandigi E, Molinaro F, Bulotta AL, Angotti R, Pavone M, Messina M.
Ital J Pediatr. 2013 Jan 23;39:6. doi: 10.1186/1824-7288-39-6.

Juvenile granulosa cell tumor of the testis: prenatal diagnosis and prescrotal approach.
Bulotta AL, Molinaro F, Angotti R, Ferrara F, Di Maggio G, Bindi E, Messina M.
Ital J Pediatr. 2012 Dec 6;38:67. doi: 10.1186/1824-7288-38-67.

Changes in plasma mass-spectral profile in course of treatment of non-small cell lung cancer patients with epidermal growth factor receptor tyrosine kinase inhibitors.
Lazzari C, Spreafico A, Bachi A, Roder H, Floriani I, Garavaglia D, Cattaneo A, Grigorieva J, Viganò MG, Sorlini C, Ghio D, Tsypin M, Bulotta A, Bergamaschi L, Gregorc V.
J Thorac Oncol. 2012 Jan;7(1):40-8. doi: 10.1097/JTO.0b013e3182307f17.

Challenging the current approaches to multiple myeloma-related bone disease: from bisphosphonates to target therapy.
Tassone P, Tagliaferri P, Rossi M, Calimeri T, Bulotta A, Abbruzzese A, Caraglia M, Neri P.
Curr Cancer Drug Targets. 2009 Nov;9(7):854-70.

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo.
Tassone P, Di Martino MT, Ventura M, Pietragalla A, Cucinotto I, Calimeri T, Bulotta A, Neri P, Caraglia M, Tagliaferri P.
Cancer Biol Ther. 2009 Apr;8(7):648-53.

In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer.
Cosco D, Bulotta A, Ventura M, Celia C, Calimeri T, Perri G, Paolino D, Costa N, Neri P, Tagliaferri P, Tassone P, Fresta M.
Cancer Chemother Pharmacol. 2009 Oct;64(5):1009-20. doi: 10.1007/s00280-009-0957-1.

In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.
Neri P, Tagliaferri P, Di Martino MT, Calimeri T, Amodio N, Bulotta A, Ventura M, Eramo PO, Viscomi C, Arbitrio M, Rossi M, Caraglia M, Munshi NC, Anderson KC, Tassone P.
Br J Haematol. 2008 Nov;143(4):520-31. doi: 10.1111/j.1365-2141.2008.07387.x.

Clinical and socio-economic correlates of quality of life and treatment satisfaction in patients with type 2 diabetes.
Nicolucci A, Cucinotta D, Squatrito S, Lapolla A, Musacchio N, Leotta S, Vitali L, Bulotta A, Nicoziani P, Coronel G; QuoLITy Study Group.
Nutr Metab Cardiovasc Dis. 2009 Jan;19(1):45-53. doi: 10.1016/j.numecd.2007.12.005.

The acquisition of an insulin-secreting phenotype by HGF-treated rat pancreatic ductal cells (ARIP) is associated with the development of susceptibility to cytokine-induced apoptosis.
Anastasi E, Santangelo C, Bulotta A, Dotta F, Argenti B, Mincione C, Gulino A, Maroder M, Perfetti R, Di Mario U.
J Mol Endocrinol. 2005 Apr;34(2):367-76.

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.
Bulotta A, Ludovico O, Coco A, Di Paola R, Quattrone A, Carella M, Pellegrini F, Prudente S, Trischitta V.
J Clin Endocrinol Metab. 2005 Feb;90(2):1176-80.

Gene expression profiling of cultured human islet preparations.
Hui H, Wang C, Li H, Bulotta A, D’Amico E, Khoury N, Nguyen E, Di Mario U, Chen IY, Perfetti R.
Diabetes Technol Ther. 2004 Aug;6(4):481-92.

The role of GLP-1 in the regulation of islet cell mass.
Bulotta A, Farilla L, Hui H, Perfetti R.
Cell Biochem Biophys. 2004;40(3 Suppl):65-78.

Novel strategies for the pharmacological management of type 2 diabetes.
Nourparvar A, Bulotta A, Di Mario U, Perfetti R.
Trends Pharmacol Sci. 2004 Feb;25(2):86-91.

Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes.
Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, Pascucci M, Checquolo S, Gradini R, Lendahl U, Frati L, Gulino A, Di Mario U, Screpanti I.
J Immunol. 2003 Nov 1;171(9):4504-11.

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.
Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R.
Endocrinology. 2003 Dec;144(12):5149-58.

GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release.
Bulotta A, Perfetti R, Hui H, Boros LG.
J Lipid Res. 2003 Aug;44(8):1559-65.

GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.
Egan JM, Bulotta A, Hui H, Perfetti R.
Diabetes Metab Res Rev. 2003 Mar-Apr;19(2):115-23.

Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1.
Bulotta A, Hui H, Anastasi E, Bertolotto C, Boros LG, Di Mario U, Perfetti R.
J Mol Endocrinol. 2002 Dec;29(3):347-60.

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.
Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U, Perfetti R.
Endocrinology. 2002 Nov;143(11):4397-408.

Increased c-met expression during ductal beta cell neogenesis in experimental autoimmune diabetes.
Bulotta A, Di Cesare E, Ponte E, Falchi M, Sciacchitano S, Cucinotta D, Taruscio D, Di Mario U, Anastasi E.
Growth Factors. 2001;19(4):259-67.

Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes.
Anastasi E, Ponte E, Gradini R, Bulotta A, Sale P, Tiberti C, Okamoto H, Dotta F, Di Mario U.
Eur J Endocrinol. 1999 Dec;141(6):644-52.

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